Leptin resistance does not induce hyperphagia in the rat
نویسندگان
چکیده
منابع مشابه
Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.
The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways. p62 deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this abnormality remained unclear. Here we report that hyperphagia due to central leptin resistance is the cause of obesity in p62(-/-) mice. We found that t...
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Both pregnancy and lactation are associated with hyperphagia, and circulating leptin levels are elevated during pregnancy but decreased during lactation in Brandt's voles, Lasiopodomys brandtii. Previous findings suggest that impaired leptin sensitivity contributes to hyperphagia during pregnancy. The present study aimed to examine whether the decreased circulating leptin level and/or hypothala...
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ژورنال
عنوان ژورنال: The Journal of Physiological Sciences
سال: 2011
ISSN: 1880-6546,1880-6562
DOI: 10.1007/s12576-011-0184-5